Key result
HELT-E2S2 score outperforms CHA2DS2-VASc for predicting ischemic stroke in Japanese NVAF patients with CIEDs.
Why the study?
The HELT-E2S2 score was suggested to be more useful than CHADS2 and CHA2DS2-VASc scores in Japanese NVAF patients, but its validity in those with cardiac implantable electronic devices needed assessment.
Does the HELT-E2S2 score improve prediction of ischemic stroke in Japanese patients with non-valvular atrial fibrillation and cardiac implantable electronic devices compared to CHADS2 and CHA2DS2-VASc scores?
Observational (n=362)
No
Does the HELT-E2S2 score improve prediction of ischemic stroke in Japanese patients with non-valvular atrial fibrillation and cardiac implantable electronic devices compared to CHADS2 and CHA2DS2-VASc scores?
The HELT-E2S2 score is a valid and superior tool compared to CHADS2 and CHA2DS2-VASc scores for predicting ischemic stroke in Japanese patients with non-valvular atrial fibrillation and cardiac implantable electronic devices.
May refine stroke risk stratification in Japanese NVAF-CIED patients; leaves open prospective validation and outcome impact.
Background: The HELT-E2S2score, a novel risk stratification system, was developed to determine the incidence of ischemic stroke in Japanese patients with non-valvular atrial fibrillation (NVAF). It has been suggested that the HELT-E2S2score is more useful than the CHADS2and CHA2DS2-VASc scores for Japanese patients with NVAF. This study determined the incidence of ischemic stroke in patients with NVAF and cardiac implantable electronic devices (CIEDs) and assessed the validity of the HELT-E2S2score in this population.
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Nakano et al. (2025) conducted an observational in Non-valvular atrial fibrillation with cardiac implantable electronic devices (n=362). HELT-E2S2 score vs. CHADS2 and CHA2DS2-VASc scores was evaluated on Prediction of ischemic stroke (c-statistic) (95% CI 0.657-0.795, p=0.025 vs CHADS2; 0.0097 vs CHA2DS2-VASc). The HELT-E2S2 score predicted ischemic stroke with a significantly higher c-statistic (0.719) than the CHADS2 and CHA2DS2-VASc scores in Japanese patients with NVAF and CIEDs.
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