Key result
18F-FDG and 18F-NaF PET show promise for diagnosing prosthetic valve endocarditis, device infections, and microcalcification.
Why the study?
Guideline recommendations for 18F-fluorodeoxyglucose positron emission tomography in suspected prosthetic valve endocarditis and cardiac device infections remain largely based on expert opinion without prospective randomized trials.
Answers are grounded in this paper and cite their sources.
Molecular imaging with 18F-FDG and 18F-sodium fluoride PET represents a promising clinical approach for the diagnostic workup and risk assessment of valvular diseases and cardiac device infections.
The use of positron emission tomography imaging with 18 F-fluorodeoxyglucose in the diagnostic workup of patients with suspected prosthetic valve endocarditis and cardiac device infection (implantable electronic device and left ventricular assist device) is gaining momentum in clinical practice. However, in the absence of prospective randomized trials, guideline recommendations about 18 F-fluorodeoxyglucose positron emission tomography in this setting are currently largely based on expert opinion. Measurement of aortic valve microcalcification occurring as a healing response to valvular inflammation using 18 F-sodium fluoride positron emission tomography represents another promising clinical approach, which is associated with both the risk of native valve stenosis progression and bioprosthetic valve degeneration in research trials. In this review, we consider the role of molecular imaging in cardiac valvular diseases, including aortic stenosis and valvular endocarditis, as well as cardiac device infections.
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Tarkin et al. (2023) conducted a review in Valvular diseases and cardiac device infection. Molecular imaging (18F-FDG PET and 18F-NaF PET) was evaluated. Molecular imaging using 18F-FDG and 18F-NaF PET is a promising approach for diagnosing prosthetic valve endocarditis, cardiac device infections, and aortic valve microcalcification.
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