Key result
Quadripolar LV leads linked to ~33% higher CRT response versus bipolar leads at six months.
Why the study?
Quadripolar LV leads in CRT enable multi-vector pacing and better stability, but direct outcome comparisons with bipolar LV leads needed evaluation.
Does a quadripolar left ventricular lead improve CRT response and clinical outcomes compared to a bipolar lead in patients receiving cardiac resynchronization therapy?
Observational (n=93)
No
Does a quadripolar left ventricular lead improve CRT response and clinical outcomes compared to a bipolar lead in patients receiving cardiac resynchronization therapy?
Absolute Event Rate: 85.48% vs 64.51%
p-value: p=0.03
In patients receiving CRT, quadripolar LV leads are associated with better echocardiographic response, improved symptoms, fewer HF hospitalizations, and lower complication rates compared to bipolar leads at 6 months.
No takes yet. Share an insight, caveat, or question.
May support quadripolar lead preference in CRT; leaves open confirmation by randomized trials.
Raj et al. (2021) conducted an observational in Heart failure (n=93). Quadripolar left ventricular lead vs. Bipolar left ventricular lead was evaluated on CRT response (≥ 5% absolute increase in left ventricle ejection fraction) (p=0.03). Quadripolar left ventricular leads in cardiac resynchronization therapy significantly improved the response rate to 85.48% compared to 64.51% with bipolar leads at six months.
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