Do LV GLS, E/e', and TAPSE detect subclinical anthracycline-induced cardiotoxicity in children with solid tumors?
LV GLS, E/e', and TAPSE are useful echocardiographic parameters for the early detection of subclinical anthracycline-induced cardiotoxicity in children with solid tumors.
BACKGROUND: Cardiotoxicity is one of the most serious chronic complications of anthracyclines therapy. Assessment of the left ventricular ejection fraction (LVEF) fails to detect subtle cardiac dysfunction of left ventricular (LV). This study aimed to detect and evaluate new parameters of subclinical anthracyclines' cardiotoxicity in children with solid tumor. METHODS: subgroup). RESULTS: . CONCLUSIONS: LV GLS is helpful in the early detection of subclinical LV dysfunction using 2D-STE. E/e' and TAPSE are other sensitive parameters in detecting subclinical cardiac dysfunction of both ventricles by TDI. These parameters show significant change with different anthracyclines' cumulative dosage, so cumulative dosage should be controlled in clinical treatment.
Hu et al. (Fri,) studied this question.