Key result
Inhibition of GATA-4 protein production using antisense cDNA blocked mechanical stretch-induced hypertrophy, limiting the proportion of myocytes with assembled sarcomeres to 13% vs 59% in controls.
Activation of GATA-4, in cooperation with a factor binding on Nkx-2.5 binding element, is essential for mechanical stretch-induced cardiomyocyte hypertrophy.
Answers are grounded in this paper and cite their sources.
GATA-4 inhibition attenuates stretch-induced hypertrophy in vitro; leaves open its role as a therapeutic target in vivo.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Pikkarainen et al. (2003) studied Cardiomyocyte hypertrophy. GATA-4 antisense cDNA vs. Control adenovirus was evaluated on Proportion of myocytes with assembled sarcomeres in response to stretch. Inhibition of GATA-4 protein production using antisense cDNA blocked mechanical stretch-induced hypertrophy, limiting the proportion of myocytes with assembled sarcomeres to 13% vs 59% in controls.
Synapse has enriched 10 related papers. Consider them for comparative context: