Key result
Healthy offspring of T2D parents show altered heart rate variability compared to controls.
Why the study?
Patients with diabetes mellitus exhibit altered cardiovascular autonomic activity, and the study aimed to evaluate early changes in cardiac autonomic modulation using heart rate variability in healthy offspring of type 2 diabetic parents compared to controls.
Does a parental history of type 2 diabetes alter cardiac autonomic modulation measured by heart rate variability in young healthy offspring?
Case-Control (n=100)
No
Does a parental history of type 2 diabetes alter cardiac autonomic modulation measured by heart rate variability in young healthy offspring?
Young healthy offspring of parents with type 2 diabetes exhibit early signs of sympathovagal imbalance characterized by vagal withdrawal, which may serve as an early marker for future diabetes risk.
Supports early autonomic imbalance in offspring of T2D parents; hypothesis-generating and requires prospective validation before clinical use.
INTRODUCTION: Children with parental history of diabetes have inherited susceptibility to develop diabetes. It has been shown that patients with Diabetes Mellitus exhibit altered autonomic activity of cardiovascular system. The present study aimed to determine the early changes in cardiac autonomic modulation by measuring the frequency domain analysis of heart rate variability among healthy subjects with parental history of type 2 diabetes and to compare it with the age and sex matched controls. The study of Cardiovascular Autonomic FunctionsMETHODOLOGY: was carried out in 50 healthy offsprings of Type 2 Diabetic Parents (Case group) and 50 healthy offsprings of Nondiabetic Parents (Control group) in the age range of 18 - 25 years randomly selected among MBBS students of J.L.N. Medical College Ajmer. Statistical Analysis is done by student t-test. Probability P value <0.05 was considered statistically signicant. In offsprings of type 2 diabetic patients signicantly lower HFRESULT: (nu) and signicantly higher LF (Nu) and LF/HF ratio were observed as compared to control group. The present study revealsCONCLUSION: that the Sympathovagal Imbalance (SVI) was due to vagal withdrawal in offspring of type 2 Diabetes Mellitus patients. Impairment in autonomic function is associated with increased risk of future diabetes. Early detection of diabetes can be used for risk stratication at early stages of life and serious consequences can be reduced.
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Dubey et al. (2022) conducted a case-control in Parental history of type 2 diabetes (n=100). Parental history of type 2 diabetes vs. Offsprings of nondiabetic parents was evaluated on Frequency domain analysis of heart rate variability (HF, LF, LF/HF ratio). Healthy offspring of type 2 diabetic parents exhibited significantly lower high-frequency and higher low-frequency heart rate variability and LF/HF ratio compared to controls.
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