Key result
Parental type 2 diabetes shows no significant association with altered autonomic function in nondiabetic offspring.
Why the study?
Does having parents with Type 2 Diabetes Mellitus affect glycemic status and cardiovascular autonomic functions in healthy nondiabetic offspring?
Cross-Sectional (n=60)
No
Does having parents with Type 2 Diabetes Mellitus affect glycemic status and cardiovascular autonomic functions in healthy nondiabetic offspring?
Absolute Event Rate: 1.29% vs 1.33%
p-value: p=0.222
Objective: Diabetes Mellitus is a group of common metabolic disorders that share the phenotype of hyperglycemia. Several distinct types of Diabetes Mellitus exist and are caused by interaction of genetics and environmental factors. Individuals with Diabetes Mellitus may develop signs of autonomic dysfunction involving cholinergic, noradrenergic and peptidergic systems. Type 2 Diabetes Mellitus has a strong genetic component. Individuals with a parent with Type 2 Diabetes Mellitus have an increased risk of Diabetes. If both parents have Type 2 Diabetes Mellitus, the risk approaches to 40%. Thus this study is designed to evaluate glycemic status and autonomic functions in nondiabetic offsprings of Type 2 diabetic parents. Method: The cross-sectional study of Glycemic status and Cardiovascular Autonomic Functions was carried out in 30 healthy offsprings of Type 2 Diabetic Parents (Study group) and 30 healthy offsprings of Nondiabetic Parents (Control group) in the age range of 18 - 21 years randomly selected among 1st MBBS students. Statistical Analysis is done by
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Tuppad et al. (2013) conducted a cross-sectional in Parental history of Type 2 Diabetes Mellitus (n=60). Offspring of Type 2 diabetic parents vs. Offspring of nondiabetic parents was evaluated on Heart rate response to Valsalva maneuver (Valsalva Ratio) (p=0.222). Nondiabetic offspring of Type 2 diabetic parents had non-significant decreases in Valsalva ratio (1.29 vs 1.33, p=0.222) and deep breathing HRV (26.25 vs 28.56, p=0.132) versus controls.
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