Key result
Type 2 diabetes patients with poor glycemic control had significantly higher cardiac autonomic dysfunction scores compared to those with good glycemic control (6.3 vs 4.5, p<0.01).
Why the study?
Does glycemic control affect cardiac autonomic function in patients with type 2 diabetes?
Cross-Sectional (n=90)
No
Does glycemic control affect cardiac autonomic function in patients with type 2 diabetes?
May link poor glycemic control to worse autonomic function in T2DM; leaves open need for prospective confirmation.
The present study was undertaken to estimate the glycosylated Hb level in type-2 diabetic subjects by cation-exchange- resin method and to study the relation between glycemic control and cardiac autonomic function. The study comprised of 90 subjects, 60 Diabetic mellitus type 2 patients and 30 age matched normal individuals. Diabetic mellitus type 2 patients were further classified in to two sub-groups, Type2 Diabetic mellitus patients with good glycemic control (HbA1c < 7) and Type2 Diabetic mellitus patients with poor glycemic control (HbA1c > 7). The basis of finding is multifactorial and may be at multiple levels of neuraxis including peripheral and central mechanisms as reviewed under pathophysiology of diabetic autonomic neuropathy.
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Bv et al. (2014) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=90). Poor glycemic control (HbA1c > 7%) vs. Good glycemic control (HbA1c < 7%) and healthy controls was evaluated on Mean autonomic score (p=<0.01). Type 2 diabetes patients with poor glycemic control had significantly higher cardiac autonomic dysfunction scores compared to those with good glycemic control (6.3 vs 4.5, p<0.01).
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