Key result
Cardiac rehab improves fitness and quality of life in HF by stimulating IGF-1/PI3K/Akt and MAPK pathways.
Why the study?
Heart failure continues to affect millions worldwide despite therapeutic advances, prompting a review of exercise-triggered molecular processes and therapies that improve cardiac performance.
Population
Patients with HF
Design
Review
Authors
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Supports mechanistic rationale for cardiac rehab in HF; leaves open need for targeted trials confirming pathway-driven outcomes.
This review highlights the molecular mechanisms, such as IGF-1/PI3K/Akt and MAPK pathway activation, by which exercise-based cardiac rehabilitation improves cardiac function and quality of life in heart failure patients.
Aleksova et al. (2022) conducted a review in Heart failure. Exercise-based cardiac rehabilitation was evaluated. Exercise-based cardiac rehabilitation improves cardiorespiratory fitness and quality of life in heart failure patients by stimulating molecular pathways such as IGF-1/PI3K/Akt and MAPK.
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