Carvedilol versus metoprolol in preventing post-operative atrial fibrillation: a systematic review and meta-analysis
Key result
Carvedilol cuts POAF ~37% vs metoprolol after CABG.
- RR 0.628
- 95% CI 0.473-0.834
- P<0.001
- n=691
Why the study?
Managing postoperative atrial fibrillation remains an area of uncertainty, and the efficacy of recommended beta-blockers may vary due to class-related differences.
Does carvedilol reduce the incidence of postoperative atrial fibrillation compared to metoprolol in patients undergoing CABG?
Population
691 patients undergoing CABG across four clinical trials
Comparison
Carvedilol vs metoprolol
Design
Systematic review and meta-analysis of clinical trials
Authors
Discussion
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Member takes
Implication
Supports preferring carvedilol over metoprolol for POAF prevention after CABG; reinforces pooled RCT evidence.
Study Design
Type
Meta-Analysis (n=691)
Structured PICO
Does carvedilol reduce the incidence of postoperative atrial fibrillation compared to metoprolol in patients undergoing CABG?
P
Population
691 patients across 4 clinical trials undergoing coronary artery bypass grafting (CABG), mean age ranging from 5 ±10 to 63±9 years.
I
Intervention
Carvedilol
C
Comparator
Metoprolol
O
Outcome
Incidence of postoperative atrial fibrillation (POAF)hard clinical
Main Result
Effect estimate: RR 0.628 (95% CI 0.473-0.834)
p-value: p=<0.001
Carvedilol is more effective than metoprolol in preventing postoperative atrial fibrillation in patients undergoing CABG, yielding a 13.95% absolute risk reduction.
Cite This Study
Askarinejad et al. (2024) conducted a meta-analysis in Postoperative atrial fibrillation in CABG patients (n=691). Carvedilol vs. Metoprolol was evaluated on Incidence of postoperative atrial fibrillation (POAF) (RR 0.628, 95% CI 0.473-0.834, p=<0.001). Carvedilol significantly reduced the incidence of postoperative atrial fibrillation compared to metoprolol in patients undergoing CABG (RR 0.628; 95% CI 0.473-0.834; p<0.001).