Key result
Carvedilol and metoprolol both significantly decreased heart rate in post-operative CABG patients with atrial fibrillation, with no significant difference in effectiveness between the two groups.
Why the study?
Does carvedilol reduce heart rate compared to metoprolol in post-operative coronary artery bypass graft surgery patients with atrial fibrillation?
Observational (n=100)
Does carvedilol reduce heart rate compared to metoprolol in post-operative coronary artery bypass graft surgery patients with atrial fibrillation?
Carvedilol and metoprolol are similarly effective in reducing heart rate for the management of post-operative atrial fibrillation in CABG patients.
May support carvedilol over metoprolol for post-CABG AF; leaves open confirmation in RCTs.
The objective of the present study is to analyse the effectiveness of carvedilol and metoprolol in the management of atrial fibrillation in post operative coronary artery bypass graft surgery patients. Atrial fibrillation occurs frequently soon after coronary artery bypass grafting and often results in increased mortality and morbidity. The incidence of post operative atrial fibrillation actually varies from 11% to 40% despite of the surgical technique and current guidelines recommend beta blockers as a medication for the prevention of atrial fibrillation after coronary artery bypass graft surgery. A prospective observational study was conducted on 100 subjects considering the inclusion and exclusion criteria and they were classified into carvedilol and metoprolol group. Heart rate was chosen as the primary parameter and statistical analysis was performed using student‘t’ test (p<0.05). There was a statistically significant decrease in the heart rate after therapy for both metoprolol and carvedilol but the difference in the effectiveness between carvedilol and metoprolol could not be significantly identified.
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Rodrigues et al. (2018) conducted an observational in Atrial fibrillation in post operative coronary artery bypass graft surgery patients (n=100). Carvedilol vs. Metoprolol was evaluated on Heart rate. Carvedilol and metoprolol both significantly decreased heart rate in post-operative CABG patients with atrial fibrillation, with no significant difference in effectiveness between the two groups.
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