What question did this study set out to answer?

To evaluate and compare the efficacy of preoperative oral amiodarone versus metoprolol in preventing postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.

October 1, 2015MedicineOpen Access

Is the Preoperative Administration of Amiodarone or Metoprolol More Effective in Reducing Atrial Fibrillation

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Why the study?

Does preoperative amiodarone compared to metoprolol reduce postoperative atrial fibrillation in patients undergoing CABG surgery?

Population

251 patients who underwent coronary artery bypass grafting (CABG) surgery

Comparison

Amiodarone tablet orally 1 week before coronary… vs Metoprolol tablet orally 1 week before surgery…

Design

RCT, Randomly divided into 2 groups

Follow-up

4 weeks

Authors

OOOruç Alper OnkErzincan Binali Yıldırım University BEBilgehan ErkutAtatürk University

Discussion

Member takes

Implication

Preoperative amiodarone or metoprolol may lower post-CABG AF risk; leaves open optimal regimen in prospective trials.

Key Points

To evaluate and compare the efficacy of preoperative oral amiodarone versus metoprolol in preventing postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.
Randomized trial conducted between January 2012 and May 2014 in 251 patients undergoing coronary artery bypass grafting surgery.
Patients were randomly allocated to receive either oral amiodarone (n = 122) or oral metoprolol (n = 129) starting one week preoperatively and continuing throughout the postoperative period.
Atrial fibrillation occurrence was evaluated from postoperative day 3 through 4 weeks, with clinical predictors identified via multivariable logistic regression analysis.
Postoperative atrial fibrillation occurred in 14 of 122 patients (11.5%) in the amiodarone group compared to 16 of 129 patients (12.4%) in the metoprolol group at 4 weeks (P = 0.612).
No statistically significant differences occurred between groups regarding intensive care unit stay, duration of hospitalization, or hospital charges (P = 0.741).
Logistic regression identified advancing age, lower left ventricular ejection fraction, increased left atrial diameter, and longer aortic cross-clamping time as significant predictors of postoperative atrial fibrillation.

Structured PICO

Does preoperative amiodarone compared to metoprolol reduce postoperative atrial fibrillation in patients undergoing CABG surgery?

Population

251 patients who underwent coronary artery bypass grafting (CABG) surgery

Intervention

Amiodarone tablet orally 1 week before coronary bypass surgery and during the postoperative period

Comparator

Metoprolol tablet orally 1 week before surgery and during the postoperative period

Outcome

Postoperative atrial fibrillation (AF) development rate evaluated between the first 3 days and 4 weeks after surgeryhard clinical

Preoperative administration of amiodarone and metoprolol demonstrated similar efficacy in preventing postoperative atrial fibrillation after CABG surgery.

Limitations

Small sample size

Cite This Study

Onk et al. (2015) studied this question.

synapsesocial.com/papers/6a71f4d6ce524a4339c538aa https://doi.org/10.1097/md.0000000000001576

Topics

Persistent AF management Atrial fibrillation Anticoagulation in AF AF ablation outcomes

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Is the Preoperative Administration of Amiodarone or Metoprolol More Effective in Reducing Atrial Fibrillation

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Topics

Is the Preoperative Administration of Amiodarone or Metoprolol More Effective in Reducing Atrial Fibrillation

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

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