What question did this study set out to answer?

To identify the most effective prophylactic drug regimen among amiodarone, propranolol, or their combination for preventing atrial fibrillation following coronary artery bypass grafting.

November 9, 2009Cardiovascular Therapeutics

Ability of Amiodarone and Propranolol Alone or in Combination to Prevent Post‐coronary Bypass Atrial Fibrillation

View Full Paper

Ask AI

Bookmark

Why the study?

Does amiodarone alone or in combination with propranolol reduce the incidence of post-CABG atrial fibrillation compared to propranolol alone in patients undergoing elective CABG?

Population

240 consecutive patients undergoing elective coronary artery bypass grafting (CABG)

Comparison

Amiodarone alone or amiodarone in combination… vs Propranolol alone, administered from…

Design

RCT, divided randomly into three groups, double-blind

Follow-up

up to post-CABG day 5

Authors

JKJavad KojuriShiraz University YMYadollah MahmoodiShiraz University of Medical Sciences MJMansoor JannatiShiraz University of Medical Sciences

Discussion

Member takes

Implication

Amiodarone regimens merit preference over propranolol alone for post-CABG AF prevention; confirms amiodarone superiority in this elective CABG RCT.

Key Points

To identify the most effective prophylactic drug regimen among amiodarone, propranolol, or their combination for preventing atrial fibrillation following coronary artery bypass grafting.
Double-blind randomized controlled trial (NCT00654290) involving 240 consecutive patients undergoing elective coronary artery bypass grafting (CABG).
Patients were randomized equally into three groups (n = 80 each) to receive propranolol, amiodarone, or both medications from preoperative day 7 through postoperative day 5.
Postoperative atrial fibrillation occurred in 16.3% (13/80) of patients in the propranolol group, compared to 6.3% (5/80) in the amiodarone group and 5.0% (4/80) in the combination group (P = 0.02 for propranolol vs. both other arms).
No statistically significant difference in atrial fibrillation rates occurred between the amiodarone-alone group (6.3%) and the combination group (5.0%).
Patient age was a statistically significant predictor of post-CABG atrial fibrillation (P = 0.034), whereas ejection fraction, comorbidities, and left atrial size were not.

Structured PICO

Does amiodarone alone or in combination with propranolol reduce the incidence of post-CABG atrial fibrillation compared to propranolol alone in patients undergoing elective CABG?

Population

240 consecutive patients undergoing elective coronary artery bypass grafting (CABG)

Intervention

Amiodarone alone (n=80) or amiodarone in combination with propranolol (n=80), administered from preoperative day 7 to post-CABG day 5

Comparator

Propranolol alone (n=80), administered from preoperative day 7 to post-CABG day 5

Outcome

Development of post-CABG atrial fibrillationhard clinical

Preoperative amiodarone, either alone or combined with propranolol, is more effective than propranolol alone in preventing post-CABG atrial fibrillation.

Cite This Study

Kojuri et al. (2009) studied this question.

synapsesocial.com/papers/6a72dcc5d8e6791e25543bd5 https://doi.org/10.1111/j.1755-5922.2009.00100.x

Topics

Atrial fibrillation Persistent AF management Anticoagulation in AF AF ablation outcomes

View Full Paper

Ask AI

Bookmark

Implication

Amiodarone regimens merit preference over propranolol alone for post-CABG AF prevention; confirms amiodarone superiority in this elective CABG RCT.

Ability of Amiodarone and Propranolol Alone or in Combination to Prevent Post‐coronary Bypass Atrial Fibrillation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Ability of Amiodarone and Propranolol Alone or in Combination to Prevent Post‐coronary Bypass Atrial Fibrillation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider