January 1, 2007Circulation JournalOpen Access

Postoperative Treatment With Carvedilol, a β-Adrenergic Blocker, Prevents Paroxysmal Atrial Fibrillation After Coronary Artery Bypass Grafting

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Why the study?

Does postoperative carvedilol prevent paroxysmal atrial fibrillation in patients undergoing scheduled isolated CABG?

Population

160 patients who underwent scheduled isolated coronary artery bypass grafting, mean age 66.5, 71% male, in…

Comparison

Carvedilol 5 or 10 mg oral daily, started on… vs No postoperative carvedilol.

Design

Cohort

Follow-up

Until hospital discharge (mean 17.0 to 22.0 days)

Authors

JTJunichi TsuboiIwate Medical University KKKohei KawazoeKansai Medical University HIHiroshi IzumotoHiroshima University

Discussion

Member takes

Implication

Carvedilol may lower paroxysmal AF after CABG; leaves open whether routine use is warranted pending randomized confirmation.

Structured PICO

Does postoperative carvedilol prevent paroxysmal atrial fibrillation in patients undergoing scheduled isolated CABG?

Population

160 patients who underwent scheduled isolated coronary artery bypass grafting (CABG), mean age 66.5, 71% male, in Japan. Key exclusions: bronchial asthma, chronic atrial fibrillation, or hemodialysis.

Intervention

Carvedilol 5 or 10 mg oral daily, started on postoperative day 1 or 2 and escalated to a maximum of 20 mg/day.

Comparator

No postoperative carvedilol (historical control group from a prior 1-year period).

Outcome

Postoperative paroxysmal atrial fibrillation (defined as episodes of atrial fibrillation persisting for over 10 min and confirmed by 12-lead electrocardiography).hard clinical

Postoperative administration of carvedilol significantly reduces the incidence of paroxysmal atrial fibrillation after coronary artery bypass grafting without adversely affecting hemodynamics.

Limitations

Limited patient cohort
Not a randomized trial
Low incidence of certain comorbidities limiting subgroup analysis
Not specifically designed to examine preoperative beta-blocker effects

Cite This Study

Tsuboi et al. (2007) studied this question.

synapsesocial.com/papers/6a972259ff8a6b2115f6e260 https://doi.org/10.1253/circj.72.588

Topics

Atrial fibrillation Persistent AF management Anticoagulation in AF AF ablation outcomes

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Postoperative Treatment With Carvedilol, a β-Adrenergic Blocker, Prevents Paroxysmal Atrial Fibrillation After Coronary Artery Bypass Grafting

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Postoperative Treatment With Carvedilol, a β-Adrenergic Blocker, Prevents Paroxysmal Atrial Fibrillation After Coronary Artery Bypass Grafting

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

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