Why the study?
Atrial fibrillation is the most common arrhythmia after open-heart surgery, and antioxidant agents may reduce postoperative complications such as postoperative AF.
Does N-acetylcysteine plus carvedilol reduce the incidence of postoperative atrial fibrillation in patients undergoing CABG surgery compared to carvedilol alone?
Population
Three hundred patients undergoing CABG surgery
Comparison
NAC plus carvedilol vs carvedilol
Design
Randomized trial
Follow-up
5 days after surgery
Authors
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Does not support adding NAC to carvedilol for POAF prevention after CABG; leaves open need for larger RCTs.
Does N-acetylcysteine plus carvedilol reduce the incidence of postoperative atrial fibrillation in patients undergoing CABG surgery compared to carvedilol alone?
The addition of N-acetylcysteine to carvedilol does not significantly decrease the incidence of postoperative atrial fibrillation in patients undergoing CABG surgery.
Jalalian et al. (2022) studied this question.
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