Key result
Each 10-mmHg rise in night-time systolic BP is linked to ~50% higher odds of albuminuria.
Why the study?
Does absolute night-time blood pressure level or dipping status have a stronger association with subclinical target organ damage in adults?
Population
1046 adult participants from the Mitchelstown Cohort recruited from primary care with complete 24-h…
Comparison
Absolute night-time blood pressure levels vs Night-time blood pressure dipping status
Design
Cross-sectional
Authors
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Night-time SBP may mark subclinical damage risk better than dipping; hypothesis-generating and requires prospective trials before any practice change.
Cohort (n=1,046)
Does absolute night-time blood pressure level or dipping status have a stronger association with subclinical target organ damage in adults?
Effect estimate: OR 1.5 (ACR ≥1.1 mg/mmol), OR 1.4 (LVH) (95% CI 1.2-1.8 (ACR), 1.1-1.8 (LVH))
Absolute night-time blood pressure level is a stronger marker of early target organ damage risk than dipping status, suggesting it may be a better therapeutic target.
O’Flynn et al. (2015) conducted a cohort in Subclinical target organ damage (n=1,046). Absolute night-time blood pressure vs. Dipping status was evaluated on Subclinical target organ damage (LVH on ECG and urine ACR ≥1.1 mg/mmol) (OR 1.5 (ACR ≥1.1 mg/mmol), OR 1.4 (LVH), 95% CI 1.2-1.8 (ACR), 1.1-1.8 (LVH)). Each 10-mmHg rise in absolute night-time systolic blood pressure increased the odds of subclinical target organ damage, including albuminuria (OR 1.5; 95% CI 1.2-1.8) and LVH (OR 1.4; 95% CI 1.1-1.8).
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