Key result
Cardiac extracellular matrix drives HF onset and progression through morphological and electrical remodeling.
Why the study?
Heart failure progression is likely specified by the impact of cardiovascular factors on cardiac extracellular matrix, but understanding its role and developing algorithms to verify individual extracellular matrix status are needed.
Understanding the role of the cardiac extracellular matrix and verifying its individual status can provide additional data on heart failure progression and help assess cardiovascular risk.
Any cardiovascular disease leads to heart failure (HF) — a complex clinical syndrome, the course of which is probably specified by the influence of cardiovascular factors on cardiac extracellular matrix (ECM). The presented literature data indicate that the cardiac ECM is an important pathophysiological link in the onset and progression of HF. The morphological and electrical remodeling negatively affects the systolic and diastolic functions of the heart. Impaired myocardial blood delivery, cellular maladaptation, atrial and ventricular arrhythmias are additional mechanisms of the influence of myocardial fibrosis on HF course. Understanding this role of ECM and the development of algorithms for verifying the individual status of ECM in cardiovascular patients can provide additional data on the course of HF, help to assess the risk of adverse cardiovascular events and effectively control the ongoing pharmacological and non-drug therapy.
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Илов et al. (2021) conducted a review in Heart failure. The cardiac extracellular matrix plays a crucial pathophysiological role in the onset and progression of heart failure through morphological and electrical remodeling.
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