Key result
Volume-overload hypertrophy induced by atrial septal defects in cats maintained normal myocardial contractility (1.32 vs 1.33 muscle lengths/sec; P>0.9) and energetics compared to controls.
Why the study?
Does surgically induced right ventricular volume overload alter myocardial contractility and energetics in cats?
Population
29 cats
Comparison
Surgically created atrial septal defects to… vs Sham-operated control cats
Design
Preclinical
Authors
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Does not implicate hypertrophy alone in dysfunction; extends experimental distinction between volume- and pressure-overload models.
Does surgically induced right ventricular volume overload alter myocardial contractility and energetics in cats?
Absolute Event Rate: 1.32% vs 1.33%
p-value: p=>0.9
Volume-overload hypertrophy does not depress myocardial contractility or alter energetics, indicating that hypertrophy alone is not the common denominator for abnormal myocardial function seen in pressure-overload hypertrophy.
Cooper et al. (1973) studied Right ventricular volume overload hypertrophy (n=29). Surgically created atrial septal defects (ASD) vs. Sham-operated control was evaluated on Maximal measured preload velocities (muscle lengths/sec) (p=>0.9). Volume-overload hypertrophy induced by atrial septal defects in cats maintained normal myocardial contractility (1.32 vs 1.33 muscle lengths/sec; P>0.9) and energetics compared to controls.