Key result
Chronic volume overload via atrial septal defect in cats resulted in right ventricular hypertrophy but maintained normal papillary muscle mechanical function and myosin ATPase activity (P>0.05).
Why the study?
Does chronic volume overload without pressure overload reduce myosin ATPase activity and mechanical function in the right ventricle of adult cats?
Population
Six adult cats
Comparison
Creation of large atrial septal defects with a… vs Control cats
Design
Preclinical
Authors
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RV hypertrophy from volume overload preserves mechanics in cats; extends overload-type distinctions but remains hypothesis-generating for humans.
Does chronic volume overload without pressure overload reduce myosin ATPase activity and mechanical function in the right ventricle of adult cats?
p-value: p=> 0.05
This study demonstrates that pressure overload, rather than hypertrophy per se, is required for the depression of myosin ATPase activity and mechanical function in the right ventricle.
Carey et al. (1979) studied Volume-overloaded right ventricular hypertrophy (n=6). Large atrial septal defects (ASD) vs. Control was evaluated on Papillary muscle mechanical function and myosin ATPase activity (p=> 0.05). Chronic volume overload via atrial septal defect in cats resulted in right ventricular hypertrophy but maintained normal papillary muscle mechanical function and myosin ATPase activity (P>0.05).
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