Key result
Right-sided heart failure in cattle linked to ~11-fold higher coronary arteriosclerosis in papillary muscle.
Why the study?
Right-sided congestive heart failure commonly occurs in cattle raised at high elevations (>2,500–3,500 m), prompting investigation of clinical cases resembling brisket disease at a moderate altitude (1,369 m).
Population
17 purebred Angus cattle (16 steers and 1 heifer) with clinical right-sided heart failure
Design
Case series
Authors
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Association in cattle suggests vascular contribution to right heart failure; leaves open causality and relevance beyond this model.
Observational (n=17)
No
Effect estimate: OR 11.3
p-value: p=<0.0001
Moxley et al. (2019) conducted an observational in Right-sided congestive heart failure (brisket disease) (n=17). In cattle with right-sided heart failure at moderate altitude, coronary arteriosclerosis was significantly more probable in papillary ventricular muscle (OR 11.3; p<0.0001) and the left ventricle.
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