Key result
Intramuscular immunization with an inactivated human rotavirus vaccine demonstrated broad cross-protective immunity among human rotavirus strains in guinea pigs and gnotobiotic piglets.
Why the study?
Does an inactivated human rotavirus vaccine induce heterotypic immunity in guinea pigs and gnotobiotic piglets?
Does an inactivated human rotavirus vaccine induce heterotypic immunity in guinea pigs and gnotobiotic piglets?
An inactivated human rotavirus vaccine induces broad cross-protective immunity in animal models, suggesting potential as a low-cost, efficacious vaccine for children.
There is substantial evidence for broad cross-reactive immunity and heterotypic protection among human rotavirus strains in children with natural infection or with monovalent Rotarix vaccination. In this commentary, we addressed this same topic by testing sera of guinea pigs and gnotobiotic piglets that were intramuscularly immunized with an inactivated human rotavirus vaccine and also demonstrated a broad cross-protective immunity among human rotavirus strains. Our findings from a single human strain in animal studies bode well for a low cost and efficacious inactivated vaccine to protect children against rotavirus disease throughout the world.
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Jiang et al. (2013) conducted an editorial in Rotavirus disease. Inactivated human rotavirus vaccine was evaluated on Cross-protective immunity. Intramuscular immunization with an inactivated human rotavirus vaccine demonstrated broad cross-protective immunity among human rotavirus strains in guinea pigs and gnotobiotic piglets.
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