Key result
In pigs, persistent AF increases LA dominant frequency ~14% and reduces tissue organization vs paroxysmal AF.
Why the study?
Little is known about epicardial frequency characteristics during the transition from paroxysmal to persistent AF, as accurate identification of high dominant frequency areas is often hampered by limited spatial resolution.
Population
Adult Yorkshire swine with AF induced by atrial tachypacing
Comparison
Persistent AF vs paroxysmal AF
Design
Preclinical experimental study
Authors
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Does not support practice changes; leaves open translation of porcine AF substrate mapping to human ablation strategies.
Absolute Event Rate: 7.4% vs 6.5%
p-value: p=0.03
High-resolution mapping in a porcine model demonstrates that the transition to persistent AF is characterized by increased dominant frequency, decreased organization index, and increased structural fibrosis.
Pong et al. (2023) studied Atrial fibrillation (n=10). Persistent atrial fibrillation vs. Paroxysmal atrial fibrillation was evaluated on Left atrial dominant frequency (Hz) (p=0.03). In a porcine model, persistent atrial fibrillation significantly increased left atrial dominant frequency (7.4 vs 6.5 Hz) and decreased tissue organization compared to paroxysmal atrial fibrillation.
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