Key result
In pigs, persistent AF is linked to ~14% higher LA epicardial dominant frequency than paroxysmal AF.
Why the study?
Little is known about epicardial frequency characteristics during the transition from paroxysmal to persistent AF, as accurate identification of high dominant frequency areas is often limited by spatial resolution.
Population
Adult Yorkshire swine with AF induced by atrial tachypacing
Comparison
Persistent AF vs paroxysmal AF
Design
Preclinical animal mapping and histological study
Authors
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Extends dominant frequency observations to persistent AF in porcine models; leaves open human translation and clinical utility.
Absolute Event Rate: 7.4% vs 6.5%
p-value: p=0.03
In a porcine model, the transition from paroxysmal to persistent AF is characterized by increased dominant frequency, decreased organization index, and increased structural fibrosis.
Pong et al. (2022) studied Persistent atrial fibrillation. Persistent AF vs. Paroxysmal AF was evaluated on Dominant frequency (DF) in the left atrial epicardium (p=0.03). In a porcine model, persistent AF was associated with a significant increase in left atrial epicardial dominant frequency compared to paroxysmal AF (7.4 vs. 6.5 Hz, P=0.03).
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