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January 2, 2014Journal of Cardiovascular Electrophysiology

Organizational Index Mapping to Identify Focal Sources During Persistent Atrial Fibrillation

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Why the study?

Does ablation of organized areas identified by organizational index mapping improve atrial fibrillation organization in remote regions in patients with persistent AF?

Population

10 patients with persistent atrial fibrillation

Comparison

Left atrial noncontact mapping and ablation of… vs All mapped sites and unablated regions

Design

Cohort

Authors

JJJulian W.E. JarmanTWTom WongPKPipin Kojodjojo

Discussion

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Overview

May promote remote AF organization after ablating organized sites; hypothesis-generating for persistent AF strategies pending trials.

Structured PICO

Does ablation of organized areas identified by organizational index mapping improve atrial fibrillation organization in remote regions in patients with persistent AF?

P
Population
10 patients with persistent atrial fibrillation
I
Intervention
Left atrial noncontact mapping and ablation of organized areas (identified by organizational index > 1 SD above mean) during wide-area circumferential ablation
C
Comparator
All mapped sites (for baseline comparison) and unablated regions (for post-ablation comparison)
O
Outcome
Dominant frequency variability (DFV) and change in organizational index (ΔOI) in remote regionssurrogate

In patients with persistent AF, sites of organized activation exhibit temporally stable activation frequencies, and targeted ablation of these focal sources leads to organization of AF in remote atrial regions.

Cite This Study

Jarman et al. (2014) studied this question.

synapsesocial.com/papers/6a20247e35281a23f90dfe05https://doi.org/10.1111/jce.12352
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Organization of Frequency Spectra of Atrial Fibrillation: Relevance to Radiofrequency Catheter Ablation2006 · 107 citations
  2. 2Spatially Distributed Dominant Excitation Frequencies Reveal Hidden Organization in Atrial Fibrillation in the Langendorff‐Perfused Sheep Heart2000 · 182 citations
  3. 3Relationship between dominant frequency, organization index, and left atrial size in patients with atrial fibrillation2020 · 6 citations
  4. 4Spatiotemporal Behavior of High Dominant Frequency During Paroxysmal and Persistent Atrial Fibrillation in the Human Left Atrium2012 · 74 citations
  5. 5High-resolution Spatiotemporal Changes in Dominant Frequency and Structural Organization During Persistent Atrial Fibrillation2022