Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2016Advanced Biomedical ResearchOpen Access

Coronary atherosclerosis evaluation among Iranian patients with zero coronary calcium score in computed tomography coronary angiography

View Full Paper
Ask AI
Bookmark
Share

Key result

Smoking, hyperlipidemia, and diabetes are linked to coronary plaques in ~4% of zero-calcium patients.

  • n=385

Why the study?

Does a zero coronary calcium score exclude the presence of noncalcified coronary plaques in patients undergoing CTCA?

Population

385 patients with a zero coronary calcium score out of 2000 consecutive patients who underwent computed…

Design

Cross-sectional

Authors

MMMaryam MoradiEVElham Varasteh

Discussion

Loading...

Member takes

Overview

Zero calcium scores do not exclude plaques in high-risk patients; leaves open whether CTCA adds value beyond calcium scoring.

Study Design

Type

Observational (n=385)

Multicenter

No

Structured PICO

Does a zero coronary calcium score exclude the presence of noncalcified coronary plaques in patients undergoing CTCA?

P
Population
385 patients with a zero coronary calcium score out of 2000 consecutive patients who underwent computed tomography coronary angiography (CTCA) at a single center in Iran.
I
Intervention
Computed tomography coronary angiography (CTCA) evaluation for noncalcified plaques
O
Outcome
Presence and extent of coronary plaques in CTCA in patients with a zero CAC scoresurrogate

A zero coronary calcium score does not absolutely exclude obstructive coronary artery disease, especially in patients with risk factors such as diabetes, hyperlipidemia, or smoking.

Limitations

  • Coronary risk stratification was not performed before inclusion
  • Cardiovascular risk factors were obtained using a self-reported questionnaire
  • Small sample size
  • Retrospective study design
  • Low sensitivity of CTCA for detecting noncalcified plaques with <50% occlusion

Cite This Study

Moradi et al. (2016) conducted an observational in Suspected coronary artery disease with zero coronary calcium score (n=385). Computed tomography coronary angiography (CTCA) was evaluated on Presence of coronary atherosclerotic plaques. Among Iranian patients with a zero coronary calcium score, 4.2% had atherosclerotic plaques, with smoking (OR 32.5), hyperlipidemia (OR 14.0), and diabetes (OR 5.9) significantly increasing the risk.

synapsesocial.com/papers/6a0ede2d37aeb0126447b2e5https://doi.org/10.4103/2277-9175.175920
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Prevalence and Extent of Coronary Atherosclerosis among Patients with a Zero Calcium Score and the Influence of Patient Characteristics2013 · 3 citations
  2. 2Atherosclerotic Plaque in Patients with Zero Calcium Score at Coronary Computed Tomography Angiography2018 · 19 citations
  3. 3Assessing the reliability of coronary artery calcium score in symptomatic patients: challenging the 'power of zero'2024 · 1 citations
  4. 4Frequency and risk factors associated with atherosclerotic plaques in patients with a zero coronary artery calcium score2011 · 8 citations
  5. 5Identification of different lipid profiles in patients with zero calcium score with or without plaques after coronary computed tomography: a prospective registry to refine primary prevention2025