Key result
Low diastolic blood pressure (<70 mmHg) was associated with an accelerated decline in creatinine clearance (1.63 vs 1.21 ml/min per yr; P=0.01) compared with DBP 70-79 mmHg in very old individuals.
Why the study?
Does low or declining blood pressure accelerate the decline of renal function in 85-year-old individuals?
Population
550 inhabitants of Leiden, The Netherlands, enrolled at their 85th birthday, 34% men.
Comparison
Low diastolic blood pressure and declining… vs Higher diastolic blood pressure categories and…
Design
Cohort
Follow-up
Up to 5 years (until death or age 90)
Authors
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Low DBP may warrant renal monitoring in the very old; hypothesis-generating for BP targets and needs prospective confirmation.
Cohort (n=550)
No
Does low or declining blood pressure accelerate the decline of renal function in 85-year-old individuals?
Absolute Event Rate: 1.63% vs 1.21%
p-value: p=0.01
In very old individuals, low diastolic blood pressure and declining blood pressure over time are associated with an accelerated decline in renal function, whereas high blood pressure is not.
Bemmel et al. (2006) conducted a cohort in Renal function decline (n=550). Low diastolic blood pressure (<70 mmHg) vs. Diastolic blood pressure 70-79 mmHg was evaluated on Decline of creatinine clearance over time (p=0.01). Low diastolic blood pressure (<70 mmHg) was associated with an accelerated decline in creatinine clearance (1.63 vs 1.21 ml/min per yr; P=0.01) compared with DBP 70-79 mmHg in very old individuals.
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