What question did this study set out to answer?

To examine whether serum from cancer patients can block the cytotoxic destruction of cultured neoplastic cells by immune blood lymphocytes.

March 15, 1971International Journal of Cancer

Blocking of cell‐mediated tumor immunity by sera from patients with growing neoplasms

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Authors

IHIngegerd HellströmUniversity of Hawaiʻi at Mānoa HSHans SjögrenLinköping University GWGlenn A. WarnerNorthwest Hospital

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Implication

In vitro laboratory study reveals serum-mediated blocking of immune lymphocyte cytotoxicity in cancer patients, indicating immune evasion during tumor progression.

Key Points

To examine whether serum from cancer patients can block the cytotoxic destruction of cultured neoplastic cells by immune blood lymphocytes.
In vitro cytotoxicity assays evaluating patient blood lymphocytes against cultured tumor cells across multiple histological types (including melanomas, carcinomas, seminomas, and sarcomas).
Testing sera from 81 patients with actively growing neoplasms and 19 symptom-free patients after tumor therapy for blocking activity against autologous and allogeneic matching tumor types.
Sera from 67 of 81 patients with growing neoplasms blocked the cytotoxic effect of immune lymphocytes against matching histological tumor cells.
Serum blocking activity was observed in only 3 of 19 symptom-free patients following successful tumor therapy.
The blocking effect was tumor-type specific and absent when sera were tested against histological tumor types distinct from the serum donor's tumor.

Cite This Study

Hellström et al. (1971) studied this question.

synapsesocial.com/papers/6a0ef389b7cc3b883f22eb71 https://doi.org/10.1002/ijc.2910070206

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Implication

In vitro laboratory study reveals serum-mediated blocking of immune lymphocyte cytotoxicity in cancer patients, indicating immune evasion during tumor progression.

Blocking of cell‐mediated tumor immunity by sera from patients with growing neoplasms

Discussion

Member takes

Implication

Key Points

Cite This Study

Blocking of cell‐mediated tumor immunity by sera from patients with growing neoplasms

Discussion

Member takes

Implication

Key Points

Cite This Study

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