Interleukin-6 Family of Cytokines Mediate Angiotensin II-induced Cardiac Hypertrophy in Rodent Cardiomyocytes
Key result
Angiotensin II increased IL-6, LIF, and cardiotrophin-1 mRNA by 6.5-, 10.2-, and 2.0-fold in cardiac fibroblasts, contributing to cardiomyocyte hypertrophy via gp130-linked signaling.
Population
Rodent cardiomyocytes and cardiac fibroblasts
Comparison
Angiotensin II stimulation, and subsequent… vs Control/mock medium
Design
Preclinical
Follow-up
24 h (for IL-6 measurement)
Authors
Discussion
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Member takes
Implication
May promote hypertrophy via fibroblast cytokines; leaves open clinical translation from this animal model.
Structured PICO
P
Population
Rodent cardiomyocytes and cardiac fibroblasts
I
Intervention
Angiotensin II stimulation, and subsequent treatment with RX435 (anti-gp130 blocking antibody), TAK044 (endothelin-A/B-R blocker), or antisense oligonucleotides against LIF and cardiotrophin-1
C
Comparator
Control/mock medium
O
Outcome
Cardiac hypertrophy measured by [(3)H]phenylalanine uptake and cell area, and cytokine expression levels (IL-6, LIF, cardiotrophin-1)surrogate
Angiotensin II induces IL-6, LIF, and cardiotrophin-1 in cardiac fibroblasts, which activate gp130-linked signaling and contribute to cardiomyocyte hypertrophy.
Cite This Study
Sano et al. (2000) studied Cardiac hypertrophy. Angiotensin II vs. Control / mock medium was evaluated on Cardiomyocyte hypertrophy ([(3)H]phenylalanine uptake and cell area). Angiotensin II increased IL-6, LIF, and cardiotrophin-1 mRNA by 6.5-, 10.2-, and 2.0-fold in cardiac fibroblasts, contributing to cardiomyocyte hypertrophy via gp130-linked signaling.