Key result
Stimulation with norepinephrine induced a 50-fold increase in IL-6 mRNA in rat cardiac fibroblasts, an effect that was almost completely prevented by the addition of carvedilol.
Effect estimate: 50-fold increase
Catecholamines stimulate IL-6 expression in rat cardiac fibroblasts, suggesting an autocrine/paracrine role for IL-6 in cardiac hypertrophy.
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Does not support clinical use of carvedilol for IL-6 suppression; leaves open translation of fibroblast findings to human cardiac disease.
Bürger et al. (2001) studied Cardiac hypertrophy. Catecholamines (norepinephrine, phenylephrine, isoproterenol) vs. Unstimulated rat cardiac fibroblasts was evaluated on IL-6 mRNA synthesis (50-fold increase). Stimulation with norepinephrine induced a 50-fold increase in IL-6 mRNA in rat cardiac fibroblasts, an effect that was almost completely prevented by the addition of carvedilol.
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