Why the study?
Does IL-6 deficiency prevent norepinephrine-induced left ventricular hypertrophy in mice?
Does IL-6 deficiency prevent norepinephrine-induced left ventricular hypertrophy in mice?
Interleukin-6 plays a crucial mechanistic role in the development of norepinephrine-induced left ventricular hypertrophy and extracellular matrix remodeling in mice.
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IL-6 may mediate norepinephrine-induced LV hypertrophy in mice; leaves open whether IL-6 inhibition prevents remodeling in humans.
Meier et al. (2009) studied this question.
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