Population
Cultured rat neonatal ventricular myocytes
Comparison
Interleukin-6 (IL-6) 50 U/ml vs Baseline measurements
Design
Preclinical
Authors
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IL-6 effects on myocyte gene expression are hypothesis-generating for hypertrophy mechanisms; requires translational validation before any clinical consideration.
IL-6 induces reciprocal changes in SERCA and natriuretic peptide mRNA expression in rat ventricular myocytes, suggesting a mechanism for IL-6-mediated cardiac hypertrophy.
Tanaka et al. (2004) studied this question.
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