Why the study?
Does genetic deletion of IL-6 attenuate pressure overload-induced left ventricular hypertrophy and dysfunction in mice?
Population
Wild-type and IL-6 knockout (IL-6(-/-)) mice, isolated cardiac myocytes, and H9c2 cells
Comparison
Genetic deletion of IL-6 (IL-6) combined with… vs Wild-type mice undergoing TAC or sham surgery
Design
Preclinical
Authors
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IL-6 deletion attenuates TAC-induced LV remodeling in mice; leaves open any role for IL-6 blockade in human pressure-overload states.
Does genetic deletion of IL-6 attenuate pressure overload-induced left ventricular hypertrophy and dysfunction in mice?
Genetic deletion of IL-6 attenuates pressure overload-induced left ventricular hypertrophy and dysfunction via CaMKII-dependent STAT3 activation, suggesting a potential therapeutic target for hypertensive heart disease.
Zhao et al. (2016) studied this question.
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