Key result
IL-6 deficiency in mice caused severe cardiac dilatation, increased interstitial collagen, altered cell populations with increased fibroblasts, and decreased capillary density.
Population
IL-6(-/-) mice and wild-type littermates; in vitro cardiac fibroblasts and myocytes
Comparison
IL-6 deficiency (genetic knockout) vs Wild-type littermates
Design
Preclinical
Authors
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IL-6 may preserve cardiac structure; leaves open its role in human remodeling and any therapeutic targeting.
Loss of IL-6 causes cardiac dysfunction by shifting cardiac cell populations, altering the extracellular matrix, and disrupting critical cell-cell interactions.
Banerjee et al. (2009) studied Cardiac dysfunction. IL-6 deficiency (IL-6(-/-) mice) vs. Wild-type littermates was evaluated on Cardiac cell populations, cardiac function, and cell-cell interactions. IL-6 deficiency in mice caused severe cardiac dilatation, increased interstitial collagen, altered cell populations with increased fibroblasts, and decreased capillary density.
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