Key result
Primary aldosteronism was associated with higher plasma IL-6 levels, left ventricular mass index, and myocardial fibrosis compared to essential hypertension.
Why the study?
Does IL-6 trans-signalling contribute to aldosterone-induced cardiac fibrosis?
Population
25 patients with primary aldosteronism and 26 patients with essential hypertension; human umbilical vein…
Comparison
Aldosterone infusion, IL-6 chemical inhibitor… vs Essential hypertension patients; control…
Design
Preclinical
Authors
Loading...
IL-6 trans-signaling may mediate aldosterone-induced fibrosis; hypothesis-generating for targeted therapies in primary aldosteronism.
Observational (n=51)
Does IL-6 trans-signalling contribute to aldosterone-induced cardiac fibrosis?
IL-6 trans-signalling mediates aldosterone-induced cardiac fibrosis, highlighting a potential therapeutic pathway to prevent cardiac remodeling.
Chou et al. (2018) conducted an observational in Primary aldosteronism (n=51). Primary aldosteronism vs. Essential hypertension was evaluated on Plasma IL-6 levels, left ventricular mass index, myocardial fibrosis, and diastolic function. Primary aldosteronism was associated with higher plasma IL-6 levels, left ventricular mass index, and myocardial fibrosis compared to essential hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: