Comparative effect of disopyramide and ethmozine in suppressing complex ventricular arrhythmias by use of a double-blind, placebo-controlled, longitudinal crossover design.
Key result
Ethmozine was superior to disopyramide in achieving near-total abolition of ventricular premature depolarizations (30% vs 0%; p<0.05) and was well tolerated without significant side effects.
Authors
Discussion
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Implication
Ethmozine may be preferred over disopyramide for ventricular premature depolarization suppression; extends randomized comparative efficacy data for Class I agents.
Study Design
Type
RCT (n=27)
Blinding
Double-blind
PICO
P
Population
Frequent ventricular premature depolarizations (VPDs) (n=27)
I
Intervention / Comparator
Ethmozine vs Disopyramide and placebo
O
Primary Outcome
Near-total abolition of ventricular premature depolarizations (VPDs), p=<0.05
Main Result
Absolute Event Rate: 30% vs 0%
p-value: p=<0.05
Cite This Study
Pratt et al. (1984) conducted an RCT in Frequent ventricular premature depolarizations (VPDs) (n=27). Ethmozine vs. Disopyramide and placebo was evaluated on Near-total abolition of ventricular premature depolarizations (VPDs) (p=<0.05). Ethmozine was superior to disopyramide in achieving near-total abolition of ventricular premature depolarizations (30% vs 0%; p<0.05) and was well tolerated without significant side effects.