Key result
At 600 mg/day, disopyramide reduced ventricular ectopic beats by 72% compared to 25% with mexiletine, though the difference disappeared when mexiletine was increased to 1000 mg/day.
Why the study?
Does oral disopyramide compared to mexiletine reduce the incidence of ventricular arrhythmias in hospitalized patients with chronic ventricular arrhythmias?
Population
15 hospitalized patients with chronic ventricular arrhythmias
Comparison
Oral disopyramide 600 mg per day vs Oral mexiletine 600 mg per day in a crossover…
Design
RCT, randomized, crossover protocol, single-blind
Follow-up
24-h tape recordings per period
Authors
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May support disopyramide 600 mg/day or mexiletine titration to 1000 mg/day; extends comparative RCT data on class I antiarrhythmic dosing.
RCT (n=15)
Single-blind
randomized crossover
Does oral disopyramide compared to mexiletine reduce the incidence of ventricular arrhythmias in hospitalized patients with chronic ventricular arrhythmias?
Absolute Event Rate: 72% vs 25%
p-value: p=≤0.01
Disopyramide 600 mg/day is more effective than mexiletine 600 mg/day for suppressing chronic ventricular arrhythmias, but mexiletine 1000 mg/day achieves comparable efficacy.
Breithardt et al. (1982) conducted an RCT in chronic ventricular arrhythmias (n=15). Disopyramide vs. Mexiletine was evaluated on Median percentage decrease in ventricular ectopic beats (p=≤0.01). At 600 mg/day, disopyramide reduced ventricular ectopic beats by 72% compared to 25% with mexiletine, though the difference disappeared when mexiletine was increased to 1000 mg/day.
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