September 1, 1981Journal of Cardiovascular Pharmacology
Comparison of the Antiarrhythmic Efficacy of Disopyramide and Mexiletine Against Stimulus-Induced Ventricular Tachycardia
Why the study?
Does the combination of disopyramide and mexiletine reduce the inducibility of ventricular tachycardia in patients with documented ventricular tachycardia and/or fibrillation?
Population
12 patients with documented ventricular tachycardia and/or fibrillation
Comparison
Oral disopyramide, mexiletine, and a combination… vs Baseline and each drug as monotherapy in a…
Design
RCT, randomized cross-over
Follow-up
42 +/- 23 weeks
Authors
Discussion
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Implication
Supports combination therapy for refractory ventricular tachycardia; extends evidence beyond monotherapy in electrophysiology-guided testing.
Structured PICO
Does the combination of disopyramide and mexiletine reduce the inducibility of ventricular tachycardia in patients with documented ventricular tachycardia and/or fibrillation?
P
Population
12 patients with documented ventricular tachycardia and/or fibrillation
I
Intervention
Oral disopyramide (600 mg/day), mexiletine (600-1000 mg/day), and a combination of both drugs
C
Comparator
Baseline (control) and each drug as monotherapy in a cross-over design
O
Outcome
Inducibility of ventricular tachycardia by programmed ventricular stimulationsurrogate
Combined administration of disopyramide and mexiletine is effective and safe for suppressing ventricular tachycardia, particularly when monotherapy fails.
Cite This Study
Breithardt et al. (1981) studied this question.