Why the study?
Does the combination of verapamil and disopyramide alter the induction of circus movement tachycardia in patients with pre-excitation?
Does the combination of verapamil and disopyramide alter the induction of circus movement tachycardia in patients with pre-excitation?
Disopyramide may reverse the AV-nodal blocking effects of verapamil due to its anticholinergic action, potentially re-enabling circus movement tachycardia in patients with pre-excitation.
No takes yet. Share an insight, caveat, or question.
Warrants caution with verapamil-disopyramide combination in pre-excitation; leaves open confirmation of tachycardia re-induction risk.
Matsuda et al. (1981) studied this question.