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April 1, 1977Annals of Internal Medicine

Smoking and Myocardial Infarction

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Key result

Cigarette smoking may induce coronary artery spasm leading to myocardial infarction with angiographically normal coronary arteries in young men.

Population

Men in the third decade of life with myocardial infarction (n=8 from referenced study)

Design

Editorial

Authors

MFMartin J. FrankBiognos (Sweden)

Discussion

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Overview

May inform smoking cessation advice for young men with MI and normal coronaries; leaves open causal confirmation of spasm in prospective studies.

Key Points

  • To propose coronary artery spasm as the mechanism causing acute myocardial infarction in young smokers with angiographically normal coronary arteries.
  • Review and clinical evaluation of previously published angiographic data from young male patients (N=8) in their third decade of life presenting with acute myocardial infarction.
  • Comparison of cigarette smoking prevalence against post-infarction coronary vessel patency observed during angiography.
  • Six of the eight young men presenting with acute myocardial infarction were identified as cigarette smokers.
  • Three of the six smoking patients exhibited radiographically patent, angiographically normal coronary arteries following infarction.
  • Transient coronary artery spasm provoked by cigarette smoking is hypothesized to cause severe temporary ischemia that spontaneously resolves prior to angiographic imaging.

Structured PICO

P
Population
Men in the third decade of life with myocardial infarction (n=8 from referenced study)
I
Intervention
Cigarette smoking
O
Outcome
Myocardial infarction with angiographically normal coronary arteries

This early correspondence hypothesizes that cigarette smoking may induce coronary artery spasm leading to myocardial infarction in young men with angiographically normal coronary arteries.

Cite This Study

Martin J. Frank (1977) conducted a letter in Myocardial infarction (n=8). Cigarette smoking was evaluated on Myocardial infarction with angiographically normal coronary arteries. Cigarette smoking may induce coronary artery spasm leading to myocardial infarction with angiographically normal coronary arteries in young men.

synapsesocial.com/papers/6a0efeb7a14f152feafa205ahttps://doi.org/10.7326/0003-4819-86-4-509_1
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Also Consider

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  1. 1TOBACCO AND CORONARY DISEASE1940 · 105 citations
  2. 2Multivariate Analysis of Risk Factors for Coronary Heart Disease1973 · 403 citations
  3. 3Prognosis of men after first myocardial infarction: mortality and first recurrence in relation to selected parameters.1968 · 192 citations
  4. 4A CORONARY PROGNOSTIC INDEX FOR GRADING THE SEVERITY OF INFARCTION1962 · 415 citations
  5. 5Influence of Propranolol on Hemodynamic Changes and Plasma Catecholamine Levels Following Cigarette Smoking and Nicotine.1966 · 23 citations