Influence of Previous Heart Failure Hospitalization on Cardiovascular Events in Patients With Reduced and Preserved Ejection Fraction
Key result
Recent HF hospitalization in HFpEF confers CV event risk comparable to unhospitalized HFrEF.
- n=7,599
Why the study?
Does the time interval from previous heart failure hospitalization influence the risk of cardiovascular death or HF hospitalization in patients with reduced and preserved ejection fraction?
Population
7,599 patients with New York Heart Association class II to IV heart failure, of whom 5,426 had a history of…
Comparison
History of previous heart failure… vs No previous heart failure hospitalization
Design
Cohort
Follow-up
median 36.6 months
Authors
Discussion
Loading...
Member takes
Implication
Recent HF hospitalization may identify high-risk HFpEF patients; hypothesis-generating for time-dependent enrichment strategies independent of EF.
Study Design
Type
RCT (n=7,599)
Structured PICO
Does the time interval from previous heart failure hospitalization influence the risk of cardiovascular death or HF hospitalization in patients with reduced and preserved ejection fraction?
P
Population
7,599 patients with New York Heart Association class II to IV heart failure (both reduced and preserved ejection fraction), of whom 5,426 had a history of previous HF hospitalization.
I
Intervention
History of previous heart failure hospitalization and the time interval since that hospitalization
C
Comparator
No previous heart failure hospitalization
O
Outcome
Composite of cardiovascular death or unplanned admission to hospital for the management of worsening HF during a median of 36.6 monthscomposite
Recent heart failure hospitalization identifies a high-risk population for future clinical trials, as the risk of cardiovascular death or readmission declines as time from prior hospitalization increases, independent of ejection fraction.
Cite This Study
Bello et al. (2014) conducted an RCT in Heart failure with reduced and preserved ejection fraction (n=7,599). Time interval between previous HF hospitalization and randomization vs. No previous HF hospitalization was evaluated on cardiovascular death or unplanned admission to hospital for the management of worsening HF. Recent heart failure hospitalization (≤6 months) in preserved EF patients conferred a risk of cardiovascular events comparable to reduced EF patients without prior hospitalization.