Key result
Abnormal right atrial electrograms were significantly more frequent in patients with paroxysmal atrial fibrillation compared to controls (76.1% vs 23.8%, p<0.001), and increased with advancing age.
Why the study?
Does advancing age correlate with an increase in abnormal right atrial electrograms in patients with and without paroxysmal atrial fibrillation?
Case-Control (n=88)
No
Does advancing age correlate with an increase in abnormal right atrial electrograms in patients with and without paroxysmal atrial fibrillation?
Absolute Event Rate: 76.1% vs 23.8%
p-value: p=<0.001
Electrophysiological abnormalities of the atrial muscle, indicative of atrial vulnerability, increase with advancing age regardless of PAF history, but the extent and age-related impact are significantly more pronounced in patients with PAF.
Age-related atrial substrate changes may inform risk stratification in older PAF patients; leaves open whether electrogram findings predict progression or guide intervention.
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Isomoto et al. (1992) conducted a case-control in Paroxysmal atrial fibrillation (n=88). Intraatrial catheter mapping vs. Control patients without paroxysmal atrial fibrillation was evaluated on Incidence of abnormal right atrial electrograms (duration ≥100 msec or ≥8 fragmented deflections) (p=<0.001). Abnormal right atrial electrograms were significantly more frequent in patients with paroxysmal atrial fibrillation compared to controls (76.1% vs 23.8%, p<0.001), and increased with advancing age.
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