Key result
Intracoronary administration of HGF-loaded microspheres 48 hours post-AMI did not significantly improve cardiac function, inflammation, or cardiac fibrosis in a swine model (p > 0.05).
Why the study?
To evaluate the cardiac safety and effectiveness of intracoronary administration of HGF-loaded extended release microspheres in an acute myocardial infarction swine model.
Does intracoronary administration of HGF-loaded microspheres improve cardiac function and reduce inflammation/fibrosis in a reperfused AMI swine model?
Does intracoronary administration of HGF-loaded microspheres improve cardiac function and reduce inflammation/fibrosis in a reperfused AMI swine model?
p-value: p=> 0.05
Intracoronary administration of HGF-loaded microspheres 48 hours post-AMI failed to improve cardiac function or reduce fibrosis in a swine model, and caused impaired coronary flow in some animals.
Intracoronary HGF microspheres showed no benefit in swine AMI; leaves open optimal delivery, timing, or formulation for future translational studies.
Therapy microencapsulation allows minimally invasive, safe, and effective administration. Hepatocyte growth factor (HGF) has angiogenic, anti-inflammatory, anti-apoptotic, and anti-fibrotic properties. Our objective was to evaluate the cardiac safety and effectiveness of intracoronary (IC) administration of HGF-loaded extended release microspheres in an acute myocardial infarction (AMI) swine model. An IC infusion of 5 × 106 HGF-loaded microspheres (MS+HGF, n = 7), 5 × 106 placebo microspheres (MS, n = 7), or saline (SAL, n = 7) was performed two days after AMI. TIMI flow and Troponin I (TnI) values were assessed pre- and post-treatment. Cardiac function was evaluated with magnetic resonance imaging (cMR) before injection and at 10 weeks. Plasma cytokines were determined to evaluate the inflammatory profile and hearts were subjected to histopathological evaluation. Post-treatment coronary flow was impaired in five animals (MS+HGF and MS group) without significant increases in TnI. One animal (MS group) died during treatment. There were no significant differences between groups in cMR parameters at any time (p > 0.05). No statistically significant changes were found between groups neither in cytokines nor in histological analyses. The IC administration of 5 × 106 HGF-loaded-microspheres 48 h post-AMI did not improve cardiac function, nor did it decrease inflammation or cardiac fibrosis in this experimental setting.
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Blanco et al. (2023) studied Acute myocardial infarction (swine model) (n=21). Intracoronary HGF-loaded extended release microspheres vs. Placebo microspheres or saline was evaluated on Cardiac function evaluated with magnetic resonance imaging (cMR) (p=> 0.05). Intracoronary administration of HGF-loaded microspheres 48 hours post-AMI did not significantly improve cardiac function, inflammation, or cardiac fibrosis in a swine model (p > 0.05).
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