April 28, 2020Scientific ReportsOpen Access

Microencapsulated Insulin-Like Growth Factor-1 therapy improves cardiac function and reduces fibrosis in a porcine acute myocardial infarction model

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Why the study?

IGF-1 shows beneficial effects after MI, and microencapsulation could potentially improve results.

Does intracoronary infusion of microencapsulated IGF-1 improve cardiac function and reduce fibrosis in a swine acute MI model?

Comparison

IGF-1 loaded microspheres vs unloaded microspheres vs saline

Design

Preclinical animal study

Follow-up

10 weeks

Authors

CBClaudia Báez-DíazCentro de Cirugía de Mínima Invasión Jesús Usón VBVirginia BlancoInstituto de Salud Carlos III FSFrancisco-Miguel Sánchez-MargalloCentro de Cirugía de Mínima Invasión Jesús Usón

Discussion

Member takes

Implication

May improve post-MI function in swine; hypothesis-generating for human translation.

Structured PICO

Does intracoronary infusion of microencapsulated IGF-1 improve cardiac function and reduce fibrosis in a swine acute MI model?

Population

Swine acute myocardial infarction (MI) model (n=24)

Intervention

Intracoronary injection of a 10 ml solution of 5 × 10^6 Insulin-like growth factor-1 (IGF-1) loaded microspheres (MSPs) performed 48 hours post-MI

Comparator

Intracoronary injection of 5 × 10^6 unloaded MSPs (n=9) or saline (n=7)

Outcome

Left ventricular ejection fraction (LVEF), indexed ventricular volumes, and infarct size (IS) determined by cardiac magnetic resonance at 10 weekssurrogate

Intracoronary injection of IGF-1 loaded microspheres improves cardiac function and limits myocardial fibrosis in a porcine acute MI model, suggesting potential clinical relevance for post-MI heart failure prevention.

Cite This Study

Báez-Díaz et al. (2020) studied this question.

synapsesocial.com/papers/6a77d5274fe2e6ffd8ed0196 https://doi.org/10.1038/s41598-020-64097-y

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April 28, 2020Scientific ReportsOpen Access

Microencapsulated Insulin-Like Growth Factor-1 therapy improves cardiac function and reduces fibrosis in a porcine acute myocardial infarction model

View Full Paper

Ask AI

Bookmark

Why the study?

IGF-1 shows beneficial effects after MI, and microencapsulation could potentially improve results.

Does intracoronary infusion of microencapsulated IGF-1 improve cardiac function and reduce fibrosis in a swine acute MI model?

Comparison

IGF-1 loaded microspheres vs unloaded microspheres vs saline

Design

Preclinical animal study

Follow-up

10 weeks

Authors

Discussion

Member takes

Implication

May improve post-MI function in swine; hypothesis-generating for human translation.

Structured PICO

Does intracoronary infusion of microencapsulated IGF-1 improve cardiac function and reduce fibrosis in a swine acute MI model?

Population

Swine acute myocardial infarction (MI) model (n=24)

Intervention

Intracoronary injection of a 10 ml solution of 5 × 10^6 Insulin-like growth factor-1 (IGF-1) loaded microspheres (MSPs) performed 48 hours post-MI

Comparator

Intracoronary injection of 5 × 10^6 unloaded MSPs (n=9) or saline (n=7)

Outcome

Left ventricular ejection fraction (LVEF), indexed ventricular volumes, and infarct size (IS) determined by cardiac magnetic resonance at 10 weekssurrogate

Cite This Study

Báez-Díaz et al. (2020) studied this question.

synapsesocial.com/papers/6a77d5274fe2e6ffd8ed0196 https://doi.org/10.1038/s41598-020-64097-y

Also Consider

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