Why the study?
Does intramyocardial injection of adenovirus encoding HGF improve cardiac function and remodeling in a rat model of post-MI heart failure?
Population
Rat model of experimental myocardial infarction, n=14
Comparison
Direct intramyocardial injection with… vs Direct intramyocardial injection with null virus…
Design
Preclinical
Follow-up
3 weeks after injection
Authors
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Hypothesis-generating for HGF gene therapy in post-MI remodeling; leaves open translation to clinical trials.
Does intramyocardial injection of adenovirus encoding HGF improve cardiac function and remodeling in a rat model of post-MI heart failure?
Overexpression of HGF 3 weeks post-MI in a rat model enhanced angiogenesis, reduced apoptosis, and preserved cardiac contractile function.
Jayasankar et al. (2005) studied this question.
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