Why the study?
Previous studies on hepatocyte growth factor for promoting angiogenesis and cardiac function after MI in pigs yielded controversial results.
Does local HGF administration improve LVEF and capillary density in pig models with myocardial infarction?
Does local HGF administration improve LVEF and capillary density in pig models with myocardial infarction?
Local HGF administration improves cardiac function, reduces infarct size, and promotes angiogenesis in pig models of myocardial infarction, suggesting potential for clinical translation.
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Clarifies HGF effects in porcine MI models; leaves open translation to human trials before clinical adoption.
Du et al. (2020) studied this question.
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