What is the clinical evidence from this study?

Study design: Observational. Population: Chronic thromboembolic pulmonary hypertension (CTEPH) (n=308). Intervention: Pulmonary thromboendarterectomy (PTE). Primary outcome: Survival at > 6 years.

What question did this study set out to answer?

This evaluation aims to assess the long-term outcomes of pulmonary thromboendarterectomy in patients with chronic thromboembolic pulmonary hypertension.

August 1, 1999American Journal of Respiratory and Critical Care Medicine

Long-Term Outcome after Pulmonary Thromboendarterectomy

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Key result

Pulmonary thromboendarterectomy offered CTEPH patients substantial long-term benefits, including a 75% survival rate at >6 years and 93% of patients achieving NYHA Class I or II.

Why the study?

Does pulmonary thromboendarterectomy improve survival, functional status, and quality of life in patients with chronic thromboembolic pulmonary hypertension?

Population

308 patients with chronic thromboembolic pulmonary hypertension who were more than 1 year post-pulmonary…

Comparison

Pulmonary thromboendarterectomy (PTE) vs Pre-PTE baseline

Design

Cohort

Follow-up

mean 3.3 years (range 1-16 years)

Authors

CACarol J. ArchibaldUniversity of California System WAWilliam R. AugerUniversity of California System PFPeter F. FedulloUniversity of California System

Discussion

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Implication

May support PTE consideration in CTEPH; leaves open need for randomized confirmation.

Key Points

This evaluation aims to assess the long-term outcomes of pulmonary thromboendarterectomy in patients with chronic thromboembolic pulmonary hypertension.
Questionnaires were mailed to 420 patients over one year post-PTE, with 308 responding.
Survival rates, functional status, quality of life, and healthcare utilization were analyzed.
Relationships between postoperative pulmonary hemodynamics and patient outcomes were assessed.
Survival after PTE was 75% at over 6 years.
Post-surgery, 62% of previously unemployed patients returned to work, and 93% were in NYHA Class I or II.
A significant relationship was found between postoperative pulmonary vascular resistance and various quality of life measures.

Study Design

Type

Observational (n=308)

Structured PICO

Does pulmonary thromboendarterectomy improve survival, functional status, and quality of life in patients with chronic thromboembolic pulmonary hypertension?

Population

308 patients with chronic thromboembolic pulmonary hypertension (CTEPH) who were more than 1 year post-pulmonary thromboendarterectomy (mean age 56 years)

Intervention

Pulmonary thromboendarterectomy (PTE)

Comparator

Pre-PTE baseline (for quality of life and employment status)

Outcome

Survival, functional status, quality of life, and health care utilizationpatient reported

Pulmonary thromboendarterectomy provides substantial long-term improvements in survival, functional status, and quality of life for patients with chronic thromboembolic pulmonary hypertension.

Cite This Study

Archibald et al. (1999) conducted an observational in Chronic thromboembolic pulmonary hypertension (CTEPH) (n=308). Pulmonary thromboendarterectomy (PTE) was evaluated on Survival at > 6 years. Pulmonary thromboendarterectomy offered CTEPH patients substantial long-term benefits, including a 75% survival rate at >6 years and 93% of patients achieving NYHA Class I or II.

synapsesocial.com/papers/6a0f1b33a7a2fed64abdb7ac https://doi.org/10.1164/ajrccm.160.2.9808109

Topics

Pulmonary embolism

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Long-Term Outcome after Pulmonary Thromboendarterectomy

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

Long-Term Outcome after Pulmonary Thromboendarterectomy

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

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Topics

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