Key result
PMAGE, a sensitive mRNA profiling technology, successfully identified early transcriptional changes preceding pathological manifestations of hypertrophic cardiomyopathy in a mouse model.
Population
Mice carrying a disease-causing mutation for hypertrophic cardiomyopathy
Design
Preclinical
Authors
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May advance early HCM biomarkers in models; hypothesis-generating with no human or clinical translation yet.
PMAGE is a highly sensitive mRNA profiling technology capable of detecting rare transcripts and identifying early transcriptional changes in a mouse model of hypertrophic cardiomyopathy.
Kim et al. (2007) studied Hypertrophic cardiomyopathy. Polony Multiplex Analysis of Gene Expression (PMAGE) was evaluated on Identification of early transcriptional changes preceding pathological manifestations. PMAGE, a sensitive mRNA profiling technology, successfully identified early transcriptional changes preceding pathological manifestations of hypertrophic cardiomyopathy in a mouse model.
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