Key result
Exercise and high-protein rehab linked to improved muscle characteristics and QoL in palliative HF.
Why the study?
To evaluate the effectiveness of a rehabilitation program for palliative care patients with heart failure and body composition disorders.
Does a 6-month rehabilitation program including exercise and a high-protein diet improve muscle mass, body mass, and quality of life in palliative patients with heart failure?
Cohort (n=298)
Does a 6-month rehabilitation program including exercise and a high-protein diet improve muscle mass, body mass, and quality of life in palliative patients with heart failure?
A 6-month rehabilitation program with exercise and a high-protein diet improves muscle characteristics and quality of life in palliative heart failure patients, particularly those with sarcopenic obesity.
Answers are grounded in this paper and cite their sources.
May support adjunctive rehab in palliative HF; leaves open confirmation via RCTs.
Aim. To evaluate the effectiveness of the rehabilitation program for palliative care patients with heart failure (HF) with body composition disorders. Material and methods. The study involved 298 patients (115 men and 183 women; mean age 61 years) with diagnosed HF and indications for palliative care. The patients were divided into clinical clusters using the сhi-square automatic interaction detection. The 1 st clinical cluster included patients with sarcopenic obesity (n=69 [23,2%]), the 3 rd cluster — patients with cardiac cachexia (n=47 [15,8%]), the 2 nd cluster occupies an intermediate position with an isolated disorder of body composition as follows: sarcopenia or obesity, or without these disorders (n=182 [61,1%]). Then, 2 groups (main and control) of 20 people each were formed from each cluster. The main groups of patients underwent a 6-month rehabilitation program with treatment corresponding to the clinical guidelines of the Ministry of Health of the Russian Federation for HF. The control groups of patients underwent only pharmacotherapy. Results. Patients from all control groups had a significant decrease in muscle mass, while in the 1 st and 2 nd clusters there was an increase in body mass, and in the 3 rd cluster — a decrease. The quality of life of patients from the control groups significantly decreased. Patients from the main groups of the 1 st and 2 nd clusters had a significant increase in muscle mass and a decrease in body weight. In patients of the 3 rd cluster, body weight continued to decrease, but muscle mass indices remained stable. The quality of life of patients from the 1 st cluster improved in all indices, and in the 2 nd cluster — in scale 2. In patients of the 3 rd cluster, the quality of life worsened. Conclusion. The rehabilitation program including exercise and a high-protein diet improved the muscle characteristics and the quality of life of palliative patients with HF. At the same time, the greatest effectiveness of the method was demonstrated in patients with sarcopenic obesity (1 st clinical cluster), and the least — in patients with cardiac cachexia (3 rd clinical cluster).
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Shevtsova et al. (2025) conducted a cohort in Heart failure in palliative care (n=298). Rehabilitation program (exercise and high-protein diet) vs. Pharmacotherapy only was evaluated on Muscle mass, body mass, and quality of life. A 6-month rehabilitation program including exercise and a high-protein diet improved muscle characteristics and quality of life in palliative heart failure patients, especially in sarcopenic obesity.
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