Key result
Oral converting enzyme inhibitor treatment influences organ function of the heart, brain, and vascular wall independently of the plasma RAS, contributing to their beneficial cardiovascular actions.
Why the study?
Do converting enzyme inhibitors exert beneficial cardiovascular effects via tissue CE inhibition independently of plasma RAS?
Do converting enzyme inhibitors exert beneficial cardiovascular effects via tissue CE inhibition independently of plasma RAS?
This review highlights that the beneficial cardiovascular actions of ACE inhibitors are partly mediated by tissue-level ACE inhibition, independent of circulating plasma RAS.
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ACE inhibitors may act via tissue-level effects; leaves open prospective trials to confirm outcome relevance independent of plasma RAS.
Unger et al. (1986) conducted a review in Cardiovascular disease. Converting enzyme (CE) inhibitors was evaluated. Oral converting enzyme inhibitor treatment influences organ function of the heart, brain, and vascular wall independently of the plasma RAS, contributing to their beneficial cardiovascular actions.
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