What question did this study set out to answer?

To investigate whether converting enzyme inhibitors exert antihypertensive effects through local inhibition of the renin-angiotensin system inside the brain.

January 1, 1983Clinical and Experimental Hypertension

Central Effects of Converting Enzyme Inhibitors

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Why the study?

Do converting enzyme inhibitors lower blood pressure via central inhibition of the renin-angiotensin system in hypertensive rat models?

Population

Stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar Kyoto (WKY) controls

Comparison

Converting enzyme inhibitors administered… vs Normotensive WKY controls or uninhibited state

Design

Review

Authors

BSBernward A. SchölkensGoethe University Frankfurt JAJi-Zhou Xiang AndHeidelberg University TUTh. UngerHeidelberg University

Discussion

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Implication

Central ACE inhibition may lower BP in hypertensive rat models; leaves open whether brain penetration contributes to clinical efficacy in humans.

Key Points

To investigate whether converting enzyme inhibitors exert antihypertensive effects through local inhibition of the renin-angiotensin system inside the brain.
Administered converting enzyme inhibitors (captopril, MK 421, or SA 446) via intracerebroventricular (i.c.v.) and peripheral routes (acute and chronic oral dosing) in conscious stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar Kyoto (WKY) controls.
Evaluated central converting enzyme activity in cerebrospinal fluid and periventricular brain tissue alongside pressor and drinking responses induced by i.c.v. angiotensin I, renin, and bradykinin.
Intracerebroventricular injection of captopril at doses that did not leak peripherally lowered blood pressure in conscious SHRSP but had no effect in normotensive WKY controls.
Central and peripheral administration of converting enzyme inhibitors inhibited converting enzyme in the cerebrospinal fluid and hypothalamus, suppressed drinking and pressor responses to central angiotensin I and renin, potentiated responses to bradykinin, and reduced central angiotensin II formation.

Structured PICO

Do converting enzyme inhibitors lower blood pressure via central inhibition of the renin-angiotensin system in hypertensive rat models?

Population

Stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar Kyoto (WKY) controls

Intervention

Converting enzyme inhibitors (captopril, MK 421, SA 446) administered systemically or intracerebroventricularly

Comparator

Normotensive WKY controls or uninhibited state

Outcome

Blood pressure and brain converting enzyme activitysurrogate

Converting enzyme inhibitors may exert part of their blood pressure-lowering effects through inhibition of the renin-angiotensin system within the brain.

Cite This Study

Schölkens et al. (1983) studied this question.

synapsesocial.com/papers/6a8564d142bffa23145e21bb https://doi.org/10.3109/10641968309048859

Topics

Hypertension management

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Implication

Central ACE inhibition may lower BP in hypertensive rat models; leaves open whether brain penetration contributes to clinical efficacy in humans.

Central Effects of Converting Enzyme Inhibitors

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Central Effects of Converting Enzyme Inhibitors

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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